Sesión Estadística, Probabilidad y Ciencias de DatosUnifying Wild Type and Mutant Proteomic Profiles Through Clustering
Nelson Villagra
Universidad Nacional de la Patagonia San Juan Bosco (UNPSJB), Argentina - Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo.
Rhodococcus jostii RHA1 is an oleaginous bacterium that accumulates triacylglycerols (TAGs) under nitrogen deprivation. The nitrogen lipid regulator (protein NlpR) controls genes related to nitrogen and lipid metabolism and is expressed only under these conditions. To investigate its role in TAG accumulation, we analyzed proteomic datasets from wild-type and {\em nlpR} mutant strains. Clustering analysis identified protein groups associated with NlpR, revealing potential regulatory interactions. These findings could help elucidate the mechanisms of TAG biosynthesis in oleaginous bacteria.
Trabajo en conjunto con: Héctor Álvarez (Universidad Nacional de la Patagonia San Juan Bosco - CONICET, Argentina), Roxana Silva (Universidad Nacional de la Patagonia San Juan Bosco - CONICET, Argentina), Martín Hernandez (Universidad Nacional de la Patagonia San Juan Bosco - CONICET, Argentina) y Gabriel Soto (Universidad Nacional de la Patagonia San Juan Bosco, Argentina).